science

[youtube http://www.youtube.com/watch?v=hAmBKQhq1-8&w=560&h=315] "The endocannabinoid system refers to a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes:

-The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems, respectively.

-The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as "endocannabinoids" and are physiological ligands for the cannabinoid receptors.

-The enzymes that synthesize and degrade the endocannabinoids. Unlike traditional neurotransmitters, endogenous cannabinoids are not stored in vesicles after synthesis, but are synthesized on demand (Rodriguez de Fonseca et al., 2004).

However, some evidence suggests that a pool of synthesized endocannabinoids (namely, 2-AG) may exist without the requirement of on-demand synthesis."

[youtube http://www.youtube.com/watch?v=FQc4iJedmfc&w=560&h=315]

"Dr. Frankel demonstrates the structure of the CBD molecule as well as it's relationship to THC. The Doctor explains some of the key differences between THC and CBD as well as some new hope in cancer research"

[youtube http://www.youtube.com/watch?v=zfiaC-2K1LM&w=560&h=315]

"From 2727 B.C. to the present, Weeds presents a brief history of cannabis"

Visualization of the Endocannabinoid System

https://www.youtube.com/watch?v=B6QWT-WP09o Cannabis facilitates wellness through your endocannabinoid system. Cannabinoid Receptors are found throughout the body - but, the most dense clusters appear in the brain and central nervous system. The endocannabinoid anandamide - which has a similar chemical structure to tetrahydrocannabinol (THC) - has been shown to inhibit human breast cancer cell proliferation (meaning it prevents metastasis!). Though this cannabinoid generally interacts with the CB1 receptors (which are found in the brain and central nervous system), it also mediates the immune system through CB2 receptors found throughout the peripheral tissues of the body.

When you ingest cannabinoids from your medical cannabis, the endocannabinoid system is spurred into action. Unlike pills and typical medicines, which overwork your liver and cause atrocious side effects, medical cannabis is treated as a more powerful version of anandamide. In other words, your body doesn't see cannabis as a poison - it sees Tylenol or Advil as a toxin! That's why you can overdose on run-of-the-mill pills and not medical cannabis. Our body is prepared to handle cannabinoids! :)

Watch the above visualization of the endocannabinoid system. This will help you understand the mechanisms involved in medical cannabis therapy!

Visualization of the Endocannabinoid System was a Master's Research Project by Leanne Chan in 2011. She composed this exceptional video in her pursuit of a Masters of Science Degree in Biomedical Communications, offered by the Institute of Medical Science at the University of Toronto. Below, you'll find a description of the content in her own words:

"The endocannabinoid signaling system is composed of the cannabinoid receptors; their endogenous ligands, the endocannabinoids; the enzymes that produce and inactivate the endocannabinoids; and the endocannabinoid transporters. The endocannabinoids are a new family of lipidic signal mediators, which includes amides, esters, and ethers of long-chain polyunsaturated fatty acids. Endocannabinoids signal through the same cell surface receptors that are targeted by Δ9-tetrahydrocannabinol (Δ9THC), the active principles of cannabis sativa preparations. The biosynthetic pathways for the synthesis and release of endocannabinoids are still rather uncertain. Unlike neurotransmitter molecules that are typically held in vesicles before synaptic release, endocannabinoids are synthesized on demand within the plasma membrane. Once released, they travel in a retrograde direction and transiently suppress presynaptic neurotransmitter release through activation of cannabinoid receptors. The endocannabinoid signaling system is being found to be involved in an increasing number of pathological conditions. In the brain, endocannabinoid signaling is mostly inhibitory and suggests a role for cannabinoids as therapeutic agents in central nervous system (CNS) disease. Their ability to modulate synaptic efficacy has a wide range of functional consequences and provides unique therapeutic possibilities."

Cannabis and Terpenoid Science

Wake up and smell the flowers! Not just the roses - but medical cannabis! As it turns out, following your nose could be your ticket to more effective medicine! Why? Terpenes.

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Terpenes are the fragrance molecules found in the cannabis plant's resin; terpenes not only contribute to the pungent aroma of these magnificent flowers - but they also help define the medical qualities of any particular strain!

As it turns out, cannabinoids aren’t alone in the trichome, and they definitely aren’t the only active compounds in your medicine; in fact, terpenes not only exhibit their own medical qualities (think aromatherapy), but they also act in synergy with cannabinoids!

This means you should be considering terpenes when you buy your medicine - not just cannabinoids!

At Bloom Room, we love terpenes! We've got live flowers in our shop to help enhance your medicinal experience. Think roses, tulips, daisies, and chrysanthemums - and how their potent fragrance can change your mood :)

We'll talk more on the subject of terpenes and cannabinoids, in the future. We're also going to write monthly articles on www.91Life.com to help further the fascinating science of terpenes! So, for now, just don't forget to smell your medicine before you medicate; Trust us, it makes all the difference!